Trauma History and Alcohol’s Effects on the Brain Combine to Make Women More Vulnerable to Alcohol Use Disorders

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Prior research has demonstrated greater addiction vulnerability in women; for example, women advance from casual substance use to addiction at a faster rate, experience more severe withdrawal symptoms, exhibit higher rates of relapse, and have less treatment success than men. A new study shows that biobehavioral interactions in alcohol use disorders (AUDs) among women are cyclical in nature: women’s greater risk of personal histories of trauma coupled with a greater vulnerability to alcohol-related brain deficits can lead to more severe AUD effects.