National Academy of Medicine Selects FAU for Substance Use, Opioid Crises Collaborative

Original post: Newswise - Substance Abuse National Academy of Medicine Selects FAU for Substance Use, Opioid Crises Collaborative

Newswise — As of 2024, approximately 2.7 million Americans aged 12 and older were estimated to have misused prescription opioids in the past year. Moreover, alcohol, cannabis, cocaine, methamphetamines, among other substances, reflect a complex landscape that requires ongoing efforts aimed at prevention, treatment and policy changes to address the various issues associated with each substance.

Florida Atlantic University was recently selected to participate in the National Academy of Medicine’s (NAM) Action Collaborative on Combatting Substance Use Opioid Crises Core Competency Implementation Pilot Project. To improve coordination and accelerate the pace of change, NAM partnered with more than 80 organizations to form the collaborative. This initiative brings together key stakeholders from the public, private and nonprofit sectors to collaboratively address critical issues posed by addiction.

Armiel Suriaga, Ph.D., an assistant professor in FAU’s Christine E. Lynn College of Nursing, will serve as the project lead. FAU joins other implementation sites across the United States in working toward advancing substance use care, workforce competency, and interprofessional education and practice by implementing the Action Collaborative’s 3Cs Framework for Pain and Unhealthy Substance Use, released in 2022.

The 3Cs Framework aims to set a standard for the minimum level of competence in pain management and substance use care expected from all health professionals to address professional practice gaps while strengthening the delivery of coordinated, interprofessional, high-quality and person-centered care.

The NAM Action Collaborative has selected 16 pilot sites from across the nation to participate in the Implementation Pilot Project. FAU was selected as one of the implementation pilot sites. The project focuses on implementing the selected 3 Cs framework, such as core knowledge domains with competencies of foundational and applied knowledge on pain and unhealthy substance use, such as  opioids, with nursing students and medical students, in collaboration with the FAU Office of Interprofessional Education and Practice (IPE&P) within the Office of the Provost.  

“Being selected to address substance use by the National Academy of Medicine is more than just an honor, it’s a pivotal chance to drive transformative change,” said Patricia Liehr, Ph.D., interim dean, FAU Christine E. Lynn College of Nursing. “The Action Collaborative is committed to proactively advancing structural solutions through comprehensive, multi-sector strategies aimed at reducing substance misuse and enhancing outcomes for those impacted by addiction. This crisis cannot be solved by any single entity alone – no organization, government agency, or sector has all the answers. It is through our collective effort that we can tackle this complex public health issue and forge a healthier, safer future for individuals, families and communities.”

The NAM Action Collaborative’s Implementation Pilot Project seeks to gain insights into the varied applications of the 3Cs Framework and the respective implementation processes. The learnings from this project will offer insight into the feasibility and utility of implementing the 3Cs Framework to improve health professional competency across the learning continuum and a diversity of interprofessional education and practice settings.

Through participation in the implementation pilot, FAU will help inform and shape the future of health professions education policy and practice. As part of the implementation pilot, the project team will engage in a dynamic learning community where they will share insights and best practices while fostering relationships and connections with other sites and Action Collaborative members. The team also will travel to Washington, D.C. to participate in a final knowledge sharing convening that will bring together representatives from the pilot sites and leaders across health professions education and training, health care delivery and policy.

Other members of the FAU project team include Ophelia Empleo-Frazier, GNP-BC, CDP, Yale School of Nursing; Ruth M. Tappen, Ed.D., Christine E. Lynn Eminent Scholar and Professor, FAU Christine E. Lynn College of Nursing; Terry Eggenberger, Ph.D., a professor and executive director of the FAU IPE&P; George R. Luck, M.D., interim associate program director, hospice and palliative medicine and associate professor of anesthesia, FAU Schmidt College of Medicine, Reynel Lavandera, Ph.D., associate professor and associate director of IPE&P for nursing, and Aloha Balza Montes, assistant IPE&P director, and FAU Ph.D. candidate.

“Addressing substance use in the context of pain and health care requires a unified effort because no single perspective can encompass the complexity of these issues,” said Suriaga. “Collaboration among researchers, clinicians, students and others will enable us to develop comprehensive solutions that address both the physiological and psychological dimensions of substance use, ultimately leading to more effective and compassionate care for our patients.”

– FAU –

About the Christine E. Lynn College of Nursing

FAU’s Christine E. Lynn College of Nursing is nationally and internationally known for its excellence and philosophy of caring science. In 2024, the College was ranked No. 4 for the Family Nurse Practitioner Master’s concentration nationwide by U.S. News and World Report, No. 17 for “Best Online Master’s in Nursing Administration and Financial Leadership Programs” and No. 32 for the “Best Online Master’s in Nursing Programs.” In 2023, FAU graduates on the Boca Raton campus earned an 81% pass rate on the National Council Licensure Examination for Registered Nurses (NCLEX-RN®) and a 100% AGNP Certification Pass Rate. The baccalaureate, master’s and DNP programs at Florida Atlantic University’s Christine E. Lynn College of Nursing are accredited by the Commission on Collegiate Nursing Education. The College is the only one in the U.S. to have all degree programs endorsed by the American Holistic Nursing Credentialing Corporation.

 

About Florida Atlantic University: Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University serves more than 30,000 undergraduate and graduate students across six campuses located along the southeast Florida coast. In recent years, the University has doubled its research expenditures and outpaced its peers in student achievement rates. Through the coexistence of access and excellence, FAU embodies an innovative model where traditional achievement gaps vanish. FAU is designated a Hispanic-serving institution, ranked as a top public university by U.S. News & World Report and a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. For more information, visit www.fau.edu.

Unveiling the Brain’s Reward Circuitry

Newswise — PHILADELPHIA (August 14, 2024) – A research team – co-led by Penn Nursing – has made a significant breakthrough in understanding the complex neural circuitry underlying reward and addiction by identifying 34 distinct subtypes of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a key brain region involved in pleasure and motivation. The findings, published in the journal Scientific Reports by Nature, offer insights into the diversity of these neurons and their potential roles in substance use disorders.

MSNs are the primary type of neuron in the NAc and have long been classified based on their expression of dopamine receptors. However, this new research reveals a far more intricate picture of MSN diversity. By analyzing a massive dataset of single-nucleus RNA sequencing data from rat brains, the researchers identified 34 distinct MSN subtypes, each with its own unique genetic profile.

“Our study challenges the traditional view of MSNs as a homogenous population,” said co-lead author Heath D. Schmidt, PhD, Professor in Penn Nursing’s Department of Biobehavioral Health Sciences. “By uncovering this level of diversity, we can begin to understand how specific MSN subtypes contribute to different aspects of reward processing and addiction.”

The researchers also found that these MSN subtypes are conserved across species, suggesting that the findings may have broad implications for human brain function and behavior. Additionally, by analyzing genetic data linked to substance use disorders, the team identified potential differences in the roles of specific MSN subtypes in these conditions.

This groundbreaking research provides a foundation for future studies aimed at developing targeted therapies for addiction and other brain disorders. By understanding the specific functions of different MSN subtypes, scientists can develop treatments that precisely target these cells, potentially leading to more effective and less harmful interventions.

This work was supported in part by a State of Pennsylvania Department of Health Nonformula Tobacco Settlement Act Grant, Pharmacogenetics of Opioid Use Disorder; National Institutes of Health grants R01 DA037897, R21 DA045792, R21 DA 057458, R21 DA 055846, NIH/NIDA DP1DA054394, K01 AA028292, and R01 AA030056; Tobacco-Related Disease Research Program (TRDRP) Grant Number T32IR5226; and Department of Veterans Affairs grant I01 BX004820. The researchers have no conflicts of interest to report.

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About the University of Pennsylvania School of Nursing

The University of Pennsylvania School of Nursing is one of the world’s leading schools of nursing. For the ninth year in a row, it is ranked the #1 nursing school in the world by QS University. For the third year in a row, our Bachelor of Science in Nursing (BSN) program is ranked # 1 in the 2023 U.S. News & World Report’s Best Colleges rankings. Penn Nursing is also consistently ranked highly in the U.S. News & World Report annual list of best graduate schools and is ranked as one of the top schools of nursing in funding from the National Institutes of Health. Penn Nursing prepares nurse scientists and nurse leaders to meet the health needs of a global society through innovation in research, education, and practice. Follow Penn Nursing on: FacebookTwitterLinkedIn, & Instagram.  

Researchers warn of dangers associated with rising kratom use

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Curious by Nature: How Addictive Are Companies Making Video Games with Dr. Puneet Manchanda

Newswise — For many years, addiction research has focused on chemical dependencies like drugs and alcohol. However, new phenomena such as video game and social media addictions are not as extensively studied. 

Dr. Puneet Manchanda from the University of Michigan’s Ross School of Business dives into the world of modern addiction. He talks about his research on how these technologies impact us and what steps can help prevent addiction.

The latest episode of the Curious by Nature podcast, titled “How Addictive Are Companies Making Video Games” featuring Dr. Puneet Manchanda, is now available on Spotify and Apple Podcast.

Curious by Nature, presented by Newswise, is a podcast for curious people. In each episode, listeners can travel briefly into the fascinating world that comes with years of dedication to one field of study. Be inspired by the many amazing things that are going on right now, some of which may have a major effect on our lives. Enjoy this concentrated knowledge from experts. We hope you can take inspiration from glimpses of innovation, dedication, and discovery.

Follow us!

Spotify Podcast: https://spoti.fi/3YC1c1q

Apple Podcast: https://apple.co/4copuPI

Study: Gaming Opens Pathways into it Careers

Newswise — If you’re worried that your kids are wasting too much of their summer playing video games, there could be an unexpected payoff in the future.

A new study by the Rutgers Education and Employment Research Center (EERC) reveals that gaming, modding, and related hobbies can form a career pathway into the high-demand IT field, especially for adolescents and teens with supportive parents.

“Students don’t realize it at first, but playing video games and having related hobbies is often really helpful when choosing a career and even while job hunting,” said Rutgers EERC Research Analyst Eliza Peterson, the lead author of the study. “For example, if they’re hosting a Minecraft server for their friends, they could parlay those skills and lessons into a Server Administration major, and later, maybe a career in that area of IT.”

As part of a larger study supported by the National Science Foundation, Rutgers researchers interviewed 43 students and alumni of the Ivy Tech Community College School of Information Technology in Indiana. The interviews, conducted over three years, revealed a common trajectory.

Most participants became interested in technology at a young age, often while bonding with their parents, and more than half of them (26 of 43) eventually developed a hobby such as gaming, modifying games (modding), coding, programming, or building computers.

As teens, they did not expect that their passion for playing Minecraft or Fortnite could eventually lead to a job. But they eventually had a revelation – what the researchers call the “hobby-to-career reckoning” – and decided to study IT in their community college.

“I realized I have a lot of fun doing this,” said one gamer who decided to change majors. “I made the switch because I realized that I felt like everyone was pushing me to [study] business. But what I really enjoyed was learning programming.”

One alumnus, now a software engineer at J.P. Morgan, described how his coding hobby prepared him for the complexities of handling IT at a large financial institution: “That’s kind of where I shine, because the sort of sloppy hobbyist coder in me has been doing that all my life.”

A recent Pew Research Center study finds that 85% of American teens play video games, and 41% play them at least once a day. Studies have shown that gaming can improve cognitive function and memory, while helping gamers to develop important soft skills.

The Rutgers study adds to this growing body of work by highlighting a pathway from the thumb-cramping World of Warcraft into the lucrative world of IT work.

There are nearly 4.5 million computer and information technology professionals in the U.S., earning a median annual wage of $104,420, according to the Bureau of Labor Statistics. That’s more than double the median annual wage for all occupations ($48,060).

More than 377,000 computer and IT job openings are expected each year, and overall employment is projected to grow “much faster” than the average for other occupations by 2032, including 25% growth for software developers and 32% for information security analysts.

Many of those future IT professionals could be playing Roblox or Brawl Stars today. But the Rutgers study notes there are several obstacles on the journey from hobby to career.

An estimated 42 million Americans lack broadband internet access, disproportionately affecting low-income families. This “digital divide” may prevent some students from developing an interest in the IT field. In addition, parental skepticism can deter some students from pursuing their passion.

While many of the participants felt supported in their decision to study IT, others were met with resistance at home. One first-generation student told the researchers that his family “didn’t get it” and urged him to enter a different field, but he pushed forward and earned an associate degree in software development.

“If you’re a parent or educator, I would encourage you to reframe the way you think about gaming,” Peterson said. “The gamers in your life could be gaining useful – and potentially lucrative – skills through these hobbies. In fact, you may even want to foster these hobbies further, and help them to see, ‘Hey, I could use this later on in life, in school or at work.’”

So the next time your teen turns on the PS5, perhaps think of it as employment training.

About the Study

Not “Just a Hobby”: The Influence of Early Interest and Hobbies on Community College IT Student Decision-Making by Eliza Peterson, Michelle Van Noy, Sam Scovill, and Renee Edwards appears in the Journal of Advanced Technical Education.

About Us

The Rutgers School of Management and Labor Relations (SMLR) is the world’s leading source of expertise on managing and representing workers, designing effective organizations, and building strong employment relationships. 

SMLR’s Education and Employment Research Center (EERC) strives to improve education and training to ensure students and workers are prepared to be successful in today’s workforce. 

Prescription painkiller misuse and addiction are widespread in chronic pain patients

Newswise — A new scientific review of 148 studies enrolling over 4.3 million adult chronic pain patients treated with prescription opioid painkillers has found that nearly one in ten patients experiences opioid dependence or opioid use disorder and nearly one in three shows symptoms of dependence and opioid use disorder.  This University of Bristol-led study, published in Addiction, provides a more accurate — and more concerning — rate of opioid misuse than has previously been calculated. 

Companies like Oxycontin manufacturer Purdue Pharma have claimed that fewer than 1% of opioid prescriptions result in problems for patients.  This new review, funded by the National Institute for Health and Care Research (NIHR),  makes clear that such claims greatly understate the risk of opioid misuse and addiction.  

The researchers divided the 148 studies into four general categories, depending on how the studies defined problematic opioid use: 

  1. dependence and opioid use disorder: 43 studies that identified problematic opioid use through diagnostic codes (formal diagnoses using precise definitions);
  2. signs and symptoms of dependence and opioid use disorder: 44 studies that looked for behaviours indicating dependence and opioid use disorder, such as craving, tolerance, or withdrawal, without use of specific diagnostic codes; 
  3. aberrant behaviour: 76 studies that looked for inappropriate or concerning behaviour, such as seeking early refills, repeated dose escalations, or frequently lost prescriptions; and
  4. at risk of dependence and opioid use disorder: 8 studies that looked for characteristics that might increase the risk of developing opioid dependence or opioid use disorder in the future; however, the characteristics do not fall within previous categories of aberrant behaviour or dependence and opioid use disorder.

Some studies reported multiple results within the same participants using different measurement criteria, so the sum of the number of studies in each category equals more than 148.  The prevalence (frequency) of problematic opioid use for each category was: 

  1. Dependence and opioid use disorder: 3%, or nearly 1 in 10 patients.
  2. Signs and symptoms of dependence and opioid use disorder: 6%, nearly 1 in 3 patients.
  3. Aberrant behaviour: 22%, more than 1 in 5 patients.
  4. At risk of dependence and opioid use disorder: 4%, nearly 1 in 8 patients.

Lead author Kyla Thomas, Professor of Public Health Medicine at the University of Bristol, explained: “Clinicians and policy makers need a more accurate estimate of the prevalence of problematic opioid use in pain patients so that they can gauge the true extent of the problem, change prescribing guidance if necessary, and develop and implement effective interventions to manage the problem.  Knowing the size of the problem is a necessary step to managing it.”

The studies in this review were predominantly from North American research and high-income countries. One hundred and six of the 148 studies were conducted between 2010 and 2021; the oldest study was from 1985.  Study size ranged from 15 to 2,304,181 patients. Due to the high heterogeneity of the studies, these findings should be interpreted with caution. 

Paper

‘Prevalence of problematic pharmaceutical opioid use in patients with chronic non-cancer pain: A systematic review and meta-analysis’ by Kyla H. Thomas et al. in Addiction

Fentanyl May Increase or Decrease Oxygen Levels Depending on Dosage

Original post: Newswise - Substance Abuse Fentanyl May Increase or Decrease Oxygen Levels Depending on Dosage

Newswise — Article title: Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience

Authors: Shinbe Choi, Michael R. Noya, Eugene A. Kiyatkin

From the authors: “We report that fentanyl’s effects are highly dose-dependent, drawing attention to the importance of better characterization to adequately respond in emergent cases of illicit fentanyl misuse.”

This study is highlighted as one of August’s “best of the best” as part of the American Physiological Society’s APSselect program.

Your Best Friend From High School? Here’s Why Their Genes Mattered

Original post: Newswise - Substance Abuse Your Best Friend From High School? Here's Why Their Genes Mattered

BYLINE: Greg Bruno

Newswise — Mom always said, “Choose your friends wisely.” Now a study led by a Rutgers Health professor shows she was onto something: Their traits can rub off on you – especially ones that are in their genes.

The genetic makeup of adolescent peers may have long-term consequences for individual risk of drug and alcohol use disorders, depression and anxiety, the groundbreaking study has found.

“Peers’ genetic predispositions for psychiatric and substance use disorders are associated with an individual’s own risk of developing the same disorders in young adulthood,” said Jessica E. Salvatore, an associate professor of psychiatry at the Rutgers Robert Wood Johnson Medical School and lead author of the study published in the American Journal of Psychiatry. “What our data exemplifies is the long reach of social genetic effects,” Salvatore said.

Socio-genomics – the influence of one person’s genotype on the observable traits of another – is an emerging field of genomics. Research suggests that peers’ genetic makeup may influence health outcomes of their friends. To test this, Salvatore and colleagues used Swedish national data to assess peer social genetic effects for several psychiatric disorders.

With an anonymized database of more than 1.5 million individuals born in Sweden between 1980 and 1998 to Swedish-born parents, the first step was to map individuals by location and by school during their teenage years. The researchers then used medical, pharmacy and legal registries documenting substance use and mental health disorders for the same individuals in adulthood.

Models were run to assess whether peers’ genetic predispositions predicted target individuals’ likelihood of experiencing substance abuse, major depression, and anxiety disorder in adulthood. Peers’ genetic predispositions were indexed with family genetic risk scores – personalized measures of genetic risk based on family history – for the same conditions.

Even when controlling for factors such as the target individuals’ own genetic predispositions and family socioeconomic factors, the researchers found a clear association between peers’ genetic predispositions and target individuals’ likelihood of developing a substance use or psychiatric disorder. The effects were stronger among school-based peers than geographically defined peers.

Within school groups, the strongest effects were among upper secondary school classmates, particularly those in the same vocational or college-preparatory track between ages 16 and 19. Social genetic effects for school-based peers were greater for drug and alcohol use disorders than major depression and anxiety disorder.

Salvatore said more research is needed to understand why these connections exist.

“The most obvious explanation for why peers’ genetic predispositions might be associated with our own well-being is the idea our peers’ genetic predispositions influence their phenotype, or the likelihood that peers are also affected by the disorder,” she said. “But in our analysis, we found that peers’ genetic predispositions were associated with target individuals’ likelihood of disorder even after we statistically controlled for whether peers were affected or unaffected.”

What is clear, Salvatore said, is what the findings mean for interventions.

“If we want to think about how to best address these socially costly disorders, we need to think more about network based and social interventions,” she said. “It’s not enough to think about individual risk.”

This research also underscores the importance of disrupting processes and risks that extend for at least a decade after attendance in school, Salvatore added. “Peer genetic influences have a very long reach,” she said.

Coauthors include Henrik Ohlsson, Jan Sundquist and Kristina Sundquist, from Lund University in Sweden; and Kenneth S. Kendler from the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University.

What Happens to Your Brain When You Drink with Friends?

Newswise — EL PASO, Texas (Aug. 6, 2024) – Grab a drink with friends at happy hour and you’re likely to feel chatty, friendly and upbeat. But grab a drink alone and you may experience feelings of depression. Researchers think they now know why this happens.

“Social settings influence how individuals react to alcohol, yet there is no mechanistic study on how and why this occurs,” said Kyung-An Han, Ph.D., a biologist at The University of Texas at El Paso who uses fruit flies to study alcoholism.

Now, Han and a team of UTEP faculty and students have taken a key step in understanding the neurobiological process behind social drinking and how it boosts feelings of euphoria. Their new study, published in a recent issue of the journal Addiction Biology, pinpoints the region of the brain that is stimulated by social drinking and may lead to a better understanding of how humans become vulnerable to Alcohol Use Disorder (AUD), a disease that affected nearly 29.5 million people just this past year, according to the National Institute on Alcohol Abuse and Alcoholism.

Turns out that tipsy fruit flies aren’t that different from intoxicated humans. Although they might seem like an unconventional choice from which to derive knowledge about human behavior, these insects share about 75% of the same genes that cause human diseases, Han explained.

Using fruit flies, Han and her team sought to demonstrate that ethanol, the alcohol in drinks, causes different reactions in solitary versus group settings and that dopamine, the brain molecule that plays a role in pleasure, motivation and learning, is a key player for this phenomenon.

The team’s experiments consisted of exposing fruit flies, either alone or in a group setting, to ethanol vapor and measuring their average speed to determine the degree of ethanol-induced response. While flies who “drank alone” displayed a slight increase in movement, flies exposed to ethanol in a group setting displayed significantly increased speed and movement.

The team then proceeded to test whether dopamine plays a role in the flies’ response to ethanol, comparing a control group whose dopamine was naturally regulated by the brain with an experimental group that had increased levels of dopamine.

The team found that the flies, regardless of whether they had normal or increased levels of dopamine, had a similar reaction to ethanol in a solitary setting — a tiny increase in activity. But in social settings, the flies with increased dopamine showed even more heightened hyperactivity than usual.  

“We demonstrated that both social settings and dopamine act together for the flies’ heightened response to ethanol,” said Han who currently serves as associate dean in the College of Science.

The team’s final task was to identify which of the five dopamine receptors in the brain is the largest contributor in this process and found that the D1 dopamine receptor was most important to flies’ reaction to ethanol in a social setting.

“The human D1 receptor gene is linked to Alcohol Use Disorder and this study provides experimental validation for it. For the team, the identification of the D1 receptor is crucial as it gives researchers at UTEP and beyond a blueprint for follow up studies,” Han explained.

“Our work is providing scientific knowledge to support the idea that the brain interprets and processes a person’s social surrounding and has that signal converge into the dopamine system that is also activated by alcohol consumption,” said Paul Rafael Sabandal, Ph.D., a research assistant professor in biological sciences and one of the study’s corresponding authors. “It gives us as researchers an idea of which brain area and components may serve as the meeting point for all the signals that contribute to AUD.”

The team’s next step is to explore the intricacies by which the D1 dopamine receptor serves as the nexus point for the signals that contribute to the ethanol, social interaction and AUD.

Han said, “The opportunity to work on projects whose positive impact can be applied at scale is one of the reasons I became a scientist. It’s humbling to know that our work has the potential to help people live better lives and our team is going to continue striving toward achieving that goal.”

Additional study authors are former UTEP undergraduates Dilean Murillo Gonzalez and Bryan Hernandez Granados, who are now at the Baylor College of Medicine Neuroscience Graduate Program and the Vanderbilt University Postbaccalaureate Program, respectively.

The research was funded by UTEP’s Orville Edward Egbert, M.D. Endowment fund.

About The University of Texas at El Paso

The University of Texas at El Paso is America’s leading Hispanic-serving university. Located at the westernmost tip of Texas, where three states and two countries converge along the Rio Grande, 84% of our 24,000 students are Hispanic, and more than half are the first in their families to go to college. UTEP offers 170 bachelor’s, master’s and doctoral degree programs at the only open-access, top-tier research university in America.

Last decade saw big decrease in teens who used commonly prescribed and misused prescription drugs

Audio

Newswise — Since 2009, U.S. high school seniors have reported steep declines in medical use, misuse and availability of the three most commonly prescribed and misused controlled substances for teens, a new University of Michigan study found. 

Researchers compared use trends, sources and perceived availability of opioids, stimulants and benzodiazepines from 2009 to 2022. The research letter detailing the findings is scheduled to appear July 24 in JAMA, the Journal of the American Medical Association.  

“To put these findings in context, the reduction over the past decade was like going from 1 in every 9 high school students using prescription drugs nonmedically down to 1 in every 40 high school students,” said Sean Esteban McCabe, U-M professor of nursing and director of the Center for the Study of Drugs, Alcohol, Smoking and Health.  

“While this decrease is encouraging, we need to be vigilant because any amount of nonmedical use poses risks, especially with the danger posed by counterfeit pills.”

Other findings from 2009 through 2022: 

  • Lifetime medical use decreased from 24% to 16%. 
  • Past-year misuse declined from 11% to 2%.
  • The percentage of adolescents who reported being given prescription medications by friends or buying them from friends, both fell by more than half. 
  • In 2009, adolescents who reported misusing prescription medications said the most common source was friends. Now, it is one’s own prescription (37%).
  • Among adolescents who reported misuse, those with multiple sources for obtaining prescription medications dropped from 56% to 29%.
  • Perceived difficulty of obtaining prescription medications for misuse declined across the three drug classes.
  • The percentage of adolescents who reported that they thought it would be impossible to get prescription drugs for misuse increased from 36% to 49%. 

School closures during COVID accounted for the largest changes because students had limited contact with each other, and opportunities to sell or give away prescription drugs to friends declined, McCabe said.

Study co-author Philip Veliz, research associate professor of nursing, said the declines may be partially due to changes in prescribing practices, especially for opioids. The study did not examine specific trends based on drug class. 

“Prescribing practices have changed dramatically because we had an opioid epidemic, which turned into a heroin epidemic, and we’re still reeling from that, especially with fentanyl,” Veliz said. “A lot of this also has to do with parents having better knowledge and oversight of these medications.”

The steep decline in teens who misused prescription medications in the past year, from 11% to 2%, surprised researchers.

“That’s a massive decline. It used to be 1 in 9 kids, now it’s an incredibly rare event at this point,” Veliz said. “The second surprise was that … nearly half of kids say it’s probably impossible to get these drugs if they want to use them nonmedically right now. That’s a big chunk of the adolescent population, and this is just off the table.” 

Another surprise is that the landscape has not returned to what it looked like before COVID, McCabe said. 

“Adolescents have found it more difficult to obtain prescription stimulants for nonmedical use in recent years, which is a positive sign,” he said. “There needs to be more attention on stimulant use and diversion, and our team is currently working on such studies to help inform clinical guidelines for ADHD and stimulant use disorder.”

This study was supported by the National Institute on Drug Abuse, and used data from 12th grade students collected in 2009 through 2022 from the Monitoring the Future study, an annual survey at University of Michigan that tracks student substance use and other related trends.

Co-authors include: Emily Pasman, Tim Wilens, Ty Schepis, Vita McCabe and Jason Ford.

Study: Adolescent use, diversion sources, and perceived difficulty of obtaining prescription medications (DOI: 10.1001/jama.2024.12030)