People Who Tend to Act Rashly When Upset May Anticipate Greater Positive and Negative Effects from Drinking Alcohol

People who tend to act rashly when upset may be more likely to expect alcohol to affect them—both positively and negatively—and may be more likely to want to drink to improve their mood. Mood changes, whether positive, negative, or neutral, did not alter these beliefs, according to a study of college students published in a recent issue of Alcohol: Clinical and Experimental Research. This study helps to inform further research on the relationship between impulsivity and alcohol misuse.

The study examined the influence of ‘negative urgency’ and different moods on the way people think about and value the effects of alcohol use as well as their cravings for those effects. People with negative urgency, an individual’s behavioral tendency to act impulsively in response to negative emotions, have been found in previous studies to be likely to consume more alcohol when they’re experiencing negative moods.

This online study of four hundred college students was conducted from March 2020 to June 2022. Students were assessed for negative urgency traits and answered questions about their emotional state and their beliefs and values about alcohol and craving before and after engaging in activities designed to influence their mood.

Contrary to the researchers’ expectations, changes in mood did not influence the beliefs of students with negative urgency about the effects drinking would have or their craving for those effects. Students with negative urgency characteristics were more likely to have increased positive and negative expectations around alcohol use as well as increased craving for positive and negative emotional reinforcement from alcohol use, regardless of mood.

Students with negative urgency were more likely to expect that alcohol use would affect them, both in positive ways and negative ways, but they were no more or less likely to consider those effects as good or bad. Students with negative urgency also reported greater desire for the emotional effects of drinking alcohol, such as to cope or to improve their moods.

The study was limited by a fairly homogenous participant pool of primarily White, non-Hispanic college students who were light to moderate drinkers; findings may not be applicable to a more diverse population. The study authors recommend further research to understand which beliefs and values about alcohol are most influenced by negative urgency and which are most associated with problem drinking to provide effective interventions to prevent high-risk drinking.

The influence of negative urgency and mood-inductions on alcohol cognitions. N. R. Wolkowicz, I. F. Augur, L. Ham.

ACER-23-5780.R1

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Michigan Medicine – University of Michigan


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Rutgers University-New Brunswick


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Cedars-Sinai


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Flinders University


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New Jersey Institute of Technology (NJIT)


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Michigan Medicine – University of Michigan


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Ohio State University Wexner Medical Center


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Ruhr-Universitat Bochum


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UC San Diego Health


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University of Granada


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Columbia University, Mailman School of Public Health


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Research Society on Alcoholism


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Research Society on Alcoholism


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Mount Sinai Health System


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Ruhr-Universitat Bochum


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Research Society on Alcoholism


Substance-Abuse Stigma Impedes Treatment in Various Ways, Scientists Say https://www.newswise.com/articles/substance-abuse-stigma-impedes-treatment-in-various-ways-scientists-say/?sc=c125
https://www.newswise.com/articles/substance-abuse-stigma-impedes-treatment-in-various-ways-scientists-say/?sc=c125 Fri, 15 Dec 2023 09:30:07 EST <img src=”https://www.newswise.com/legacy/image.php?image=/images/uploads/2023/12/15/657c69b968da2_Dec23-PSPI-Issue-Featured.jpg&width=100&height=150″ alt=”Newswise image” />Addiction is one of society’s most misunderstood and rebuked health conditions. That stigma discourages many people from seeking treatment for substance dependence, according to a new scientific report.
Association for Psychological Science


Facial symmetry doesn’t explain “beer goggles” https://www.newswise.com/articles/facial-symmetry-doesn-t-explain-beer-goggles/?sc=c125
https://www.newswise.com/articles/facial-symmetry-doesn-t-explain-beer-goggles/?sc=c125 Thu, 14 Dec 2023 03:05:00 EST A new study led by the University of Portsmouth in England has tested the hypothesis that people are more likely to find someone attractive while drunk, because their face appears more symmetrical.
University of Portsmouth


Long COVID can happen to anyone. Keep up with the latest research on Long COVID on Newswise

According to the CDC, Long COVID or Post-COVID Conditions (PCC) is broadly defined as signs, symptoms, and conditions that continue or develop after acute COVID-19 infection. Long COVID can happen to anyone, whether you’re otherwise healthy or have other health conditions.  Experts don’t know why people get long COVID yet, but we are getting closer.

Stay informed! These are the latest research articles on Long COVID from the Coronavirus News Source on Newswise.

Long COVID-19 is linked to chronic pain conditions

-Michigan Medicine – University of Michigan

Long COVID linked to persistently high levels of inflammatory protein: a potential biomarker and target for treatments

-University of Cambridge

How COVID-19 affects the brain

-Charité – Universitätsmedizin Berlin

Children’s Hospital Los Angeles RECOVER Study Collaborators Publish Comprehensive Report on Long COVID Symptoms in Children

-Children’s Hospital Los Angeles

BIPOC individuals bear greater post-COVID burdens

-University of Washington School of Medicine

Complement system causes cell damage in Long Covid

-University of Zurich

Study Finds Paxlovid Treatment Does Not Reduce Risk of Long COVID

-University of California, San Francisco (UCSF)

‘Long flu’ has emerged as a consequence similar to long COVID

-Washington University in St. Louis

Physical Therapy for Long COVID: Research Shows Patients Benefit

-Philadelphia College of Osteopathic Medicine

Long COVID happens in nursing homes, too, study finds

-Michigan Medicine – University of Michigan

 

 

Geographic disparities in access to addiction treatment medication may be linked to race, ethnicity

Newswise — Buprenorphine, a life-saving medication for opioid use disorder, is far less accessible in geographic areas of the United States with racially and ethnically diverse populations than in predominantly white areas, according to a new study of pre-pandemic data led by health policy scientists at the University of Pittsburgh School of Public Health published today in Journal of Addiction Medicine. 

The study is among the first to examine buprenorphine access at the local, sub-county level, and the findings point to lack of access to medications for opioid use disorder as a potential contributing reason why overdose deaths are rising most rapidly among Black Americans and Native Americans.

“The degree is rather striking,” said lead author Coleman Drake, Ph.D., assistant professor in the Department of Health Policy and Management at Pitt Public Health. “Access is substantially better in areas that are very white. When you move to areas with even some racial or ethnic diversity, there is a large decline in the geographic availability of buprenorphine prescribers and prescription fills. In areas that are less than 95 % white, for example, there’s a 45 to 50 % drop.” 

The team examined the numbers of buprenorphine prescribers and dispensed buprenorphine prescriptions within geographic regions—ZIP codes and surrounding areas within a 30-minute drive—in 2018.

The more ethnically and racially diverse ZIP codes had 45% to 55% fewer buprenorphine prescribers in urban areas and 62% to 79% fewer prescribers in rural areas. Dispensed prescriptions reflected these inequities, as well, with 51% to 76% fewer dispensed in diverse urban areas and 68% to 87% fewer in diverse rural areas. 

Unfortunately, said Drake, efforts leading up to 2018 to increase the number of buprenorphine prescribers have not resulted in equitable access to this treatment. Addressing these disparities will require a two-fold strategy: increasing the number of buprenorphine prescribers in diverse communities and, particularly in urban areas, promoting increased prescribing among those already prescribing the treatment, he said.  Additional studies are also needed to determine how more recent changes in provider requirements for prescribing buprenorphine, as well as an increase in telehealth flexibilities, have impacted these health disparities.

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About the University of Pittsburgh School of Public Health 

Founded in 1948, the University of Pittsburgh School of Public Health is a top-ranked institution of seven academic departments partnering with stakeholders locally and globally to create, implement and disseminate innovative public health research and practice. With hands-on and high-tech instruction, Pitt Public Health trains a diverse community of students to become public health leaders who counter persistent population health problems and inequities. 

College Students Appear Resistant to Using 988 Crisis Phone Line

Original post: Newswise - Substance Abuse College Students Appear Resistant to Using 988 Crisis Phone Line

Newswise — Alexandria, Va. (February 20, 2024) — The 988 Suicide and Crisis Lifeline launched across the U.S. nearly 2 years ago. But college students — who are particularly vulnerable to substance use problems and related mental health crises — appear disinclined to use it, according to new research published in the Journal of Addiction & Offender Counseling, a publication of the American Counseling Association.

“While the 988 Lifeline is intended to be used for substance use crises, the majority of students would not refer to this service for said concern,” Georgia State University doctoral student Afroze N. Shaikh and her colleagues concluded in their research. “Further effort is needed to assist college students in gaining awareness of crisis resources while supporting the agency to make informed decisions regarding their substance use.”

According to federal government data, 8.2 million adults ages 18–25 meet the criteria for a substance use disorder. Researchers have identified a link between substance use, depression and suicidal thinking, but studies also show that college-age students are unlikely to seek help for substance use and mental health problems.

The U.S. Department of Health and Human Services helped launch the 988 Lifeline in 2022 to provide an easy-to-remember dial code, akin to 911, for people in need of emergency help during a mental health crisis. Shaikh and her colleagues wanted to assess college students’ intentions to call or text 988 for substance use concerns. They recruited 446 undergraduates at a university in the southeastern U.S. and had them anonymously fill out a battery of questionnaires. The participants anonymously rated their level of tobacco, alcohol, marijuana and other drug use within the previous three months. They also were asked about their use of and experience with the 988 service.

More than 60% of the students reported using drugs or alcohol less than once a month or not at all. Roughly 18% reported daily or near-daily substance use, and another 10% reported weekly use.

Overall, the students said they were most likely to seek help from a friend or intimate partner for mental health problems and suicidal thoughts. They indicated that if they ever were to call 988, it would be for help with depression, anxiety or emotional distress. Only 15% said they’d use it for help with substance use problems. Fewer than 20% of the heaviest substance users indicated they would use the Lifeline for help.

The researchers cautioned that their study relied on self-reports — which can’t account for participants’ biases or lies — and involved mostly heterosexual, cisgender students at a single university. They called for more research involving a wider range of settings and cultural identities. 

However, the findings signal the need for colleges and universities to guide students in making informed decisions about their substance use, they wrote. In addition, state governments can make sure students and other individuals in crisis know about the new crisis number. College counselors may consider developing resource guides for students that include suicide risk factors and crisis resources, including the 988 Lifeline, they added.

Shaikh’s collaborators on the study were her Georgia State colleagues Alec Prince and Mark Burgan; San Diego professional counselor Lauren Flynn; Virginia Tech doctoral student Alexis Isaac; and Jamian Coleman, PhD, of the University of Tennessee, Knoxville.

The study, “Implications of the 988 suicide and crisis lifeline among college students experiencing substance use crises,” is available at https://doi.org/10.1002/jaoc.12131.

NOTE TO JOURNALISTS: To schedule an interview with the authors, please contact ACA at [email protected].

Founded in 1952, the American Counseling Association (ACA) is a not-for-profit, professional and educational organization that is dedicated to the growth and enhancement of the counseling profession. ACA represents nearly 60,000 members and is the world’s largest association exclusively representing professional counselors in various practice settings. Driven by the belief that all people can benefit from the power of counseling, ACA’s mission is to promote the professional development of counselors, advocate for counselors, and ensure that ethical, culturally inclusive practices protect our members’ clients and all people who seek counseling services.

Scientists discover hidden army of lung flu fighters

Newswise — Scientists have long thought of the fluid-filled sac around our lungs merely as a cushion from external damage. Turns out, it also houses potent virus-eating cells that rush into the lungs during flu infections.

Not to be confused with phages, which are viruses that infect bacteria, these cells are macrophages, immune cells produced in the body. 

“The name macrophage means ‘big eater.’ They gobble up bacteria, viruses, cancer cells, and dying cells. Really, anything that looks foreign, they take it up and destroy it,” said UC Riverside virologist Juliet Morrison, who led the discovery team. “We were surprised to find them in the lungs because nobody has seen this before, that these cells go into the lung when there’s an infection.”

A paper published in the Proceedings of the National Academy of Sciences details how during an influenza infection, macrophages leave the exterior cavity and cross into the lungs where they decrease inflammation and reduce levels of disease. 

“This study shows it’s not just what happens in the lung that matters, but also what’s outside of the lung. Cell types not normally connected to the lung can have outsized impacts on lung disease and health,” Morrison said. 

There are three main cavities in the body: one around the heart, the abdominal cavity, and the pleural cavity surrounding the lungs. “Because it contains fluid, it prevents the lungs from collapsing. However, people have not thought much about the pleural cavity being a whole organ within itself. This research may change that perception,” Morrison said.

Initially, the researchers set out to understand the more general question of what types of cells are present in the lungs during flu infections. They took existing data on lung-related genes from studies of mice that either died from the flu or survived. They then mined the data using an algorithm to predict cell types that change in the lungs during infections. 

“We took big data and broke it down to assign which potential immune cells are in the lung tissues. That’s where I got a hint that maybe we had a previously unknown external source of cells in the lung,” Morrison said. 

Next, using a laser-based technique, the team tracked macrophages going into the lungs of mice, and observed what happened if they took these cells out of the equation. “When you take them out of the mouse you see more disease and more lung inflammation,” Morrison said. 

Morrison says she hopes this study will encourage other scientists to reevaluate data sets from older studies. “Our approach was to take information already out there and put it to new use, and we were able to see something new,” she said. 

Moving forward, the research team is hoping to determine which proteins “tell” the macrophages to move into the lungs. Once the protein signals have been identified, it may be possible to create drugs that boost either the number of macrophages, or their activity.

The strategy of boosting human defenses to infection, rather than developing another antiviral, could offer people a flu treatment that would be more effective for much longer. Morrison became interested in host therapeutics because antibiotic and antiviral resistance to drugs is a growing problem.

This problem occurs when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. Misuse and overuse of the drugs is accelerating the problem. According to the Centers for Disease Control and Prevention, more than 2.8 million drug-resistant infections occur each year in the U.S., and more than 35,000 people die as a result. 

“If we can boost what resolves infection in us, we probably have a better shot. We’re less likely to have resistance. The immune system is so complicated, but it’s our best bet in the long run to work with what we have rather than chase viruses that continue to escape our therapeutics,” Morrison said. 

Borderline personality disorder patients more likely to seek hospital care

Newswise — A new study by Flinders University has uncovered links between a patient’s initial diagnosis of Borderline Personality Disorder, or BPD, and their recurrent visits to hospital.

The study investigated associations between patients with BPD and their hospital presentations as well as the effect of inpatient length of stay on time to hospital re-presentation. 

The study reviewed a South Australian (SA) cohort of 86,740 Emergency Department (ED) and inpatient episodes of care for 25,619 mental patients presenting to SA public hospitals between 2014 and 2019.

Patients with BPD were at higher risk of returning to hospital when compared to patients with any other type of mental disorder says lead author Dr David Smith from the College of Medicine and Public Health.

BPD is the most common personality disorder in Australia, affecting up to 5 per cent of the population at some stage.  It is a complex mental disorder that is often misunderstood. 

BPD patients frequently present with other co-occurring problems, including substance abuse, depression, anxiety, and bipolar affective disorder.  Furthermore, BPD is associated with considerable psychosocial impairment, including poor social functioning, unemployment, and loss of income.

Worryingly BPD patients have high rates of self-harm and suicide, leading to frequent presentations to emergency departments and mental health services with a reported mortality rate of up to 10 per cent.

“We found that approximately four per cent of all mental health patients were discharged from an Emergency Department (ED) or inpatient admission with a diagnosis of BPD recorded as the primary discharge diagnosis. Those patients were then at higher risk of hospital re-admission compared to other mental health diagnostic groups in this study cohort,” says Dr Smith.

“Of particular interest is the association between initial inpatient length of stay in hospital and the number of days before they sought hospital treatment again.

“Those patients whose initial stay in hospital was up to 14 days returned to hospital on average 58 days sooner than those patients who stayed for two days or less,” he says.

Dr Smith says that further research, such as a more detailed pathway analysis, could determine factors that predicted whether, for BPD, any overnight stay and stays of less or greater than two days were associated with harm or benefit.

“There is no doubt that more needs to be done to provide better healthcare pathways for patients with BPD.  We need to get more accurate recordings of BPD patients, and related presentations, more in-depth investigations of care pathways, and identifications of individuals who may benefit from a specific inpatient length of stay.

“We’d like to trace the patient’s journey in hospital from the patient’s perspective that would allow clinicians and managers to see and understand patients’ experience by separating the management of a specific psychiatric condition and treatment into a series of consecutive events or steps (for example, activities, interventions, or staff interactions). 

“This approach would also need to address BPD-related questions about sex and gender, such as how do sex and gender intersect with age, race and ethnicity, and other sociocultural factors as well as determine outcomes.

“The synthesis of this type of information with data, such as from the current study, would provide deeper insights into patient journeys, including when things went right and when they did not,” says Dr Smith.

“We believe that building on existing resources would improve health and community-based services and staff training, and not only boost the health and wellbeing of all Australians but significantly contribute to a reduction in emergency department presentations and hospital admissions,” Dr Smith adds.

Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer

Newswise — A new, cutting-edge study from the University of Ottawa (uOttawa) has found vanoxerine, a drug initially developed for the treatment of cocaine addiction, could impede advanced colorectal cancer stem cells by essentially re-wiring critical gene networks.

This new research published in Nature Cancer led by Dr. Yannick BenoitPrincipal Investigator and Associate Professor in the Department of Cellular and Molecular Medicine (Faculty of Medicine) at uOttawa, has revealed that vanoxerine plays an entirely unexpected mechanism in cancer. The investigators observed that vanoxerine packs a powerful punch when suppressing cancer stem cell activity in colon cancer patients’ tissues and in tumours implanted in laboratory animals. It interferes with a protein that transports dopamine, the brain chemical involved in sensations of pleasure and reward, and represses an enzyme dubbed G9a in colorectal tumours.

“Notably, the tumours treated with vanoxerine become more susceptible to attack by the immune system due to the reactivation of ancient viral DNA fragments accumulated in our genome throughout evolution. This finding is quite significant, considering that colorectal tumours tend to show poor response to standard immunotherapy,” says Dr. Benoit, who was one of six national winners of the Gairdner Foundation’s 2022 Early Career Investigator competition.

A silent killer

Colorectal cancer – when cells grow and divide uncontrollably in the colon or rectum – is the world’s second leading cause of cancer-related deaths and is considered a “silent cancer” since it typically doesn’t cause symptoms during early stages. While the risks increase with age, new statistics show an alarming increase among younger adults.

Because it’s frequently diagnosed at advanced stages when treatment options are few, it is imperative to discover new methods of beating back colorectal cancer cells and tumours. When seeking a drug safely tested in patients, the most promising option turned out to be vanoxerine, a dopamine reuptake inhibitor.

The research team observed such minimal toxicity from vanoxerine treatments when testing in healthy human and mouse tissues that Dr. Benoit says their work potentially floats “a safe way to eliminate cancer stem cells in colorectal tumours without harming the ‘good stem cells’ in the body’s organs.”

New and promising treatment

While prevention and early detection remain the best weapons against colorectal cancer, these highly compelling findings may pave the way for a new and promising treatment option for patients struggling with advanced disease.

“For those unfortunate people diagnosed with advanced and aggressive forms of colorectal cancer, we profoundly hope our work can lead to the development of powerful options for treatment in the future and substantially increase their survival chances,” says Dr. Benoit.

Roots of collaboration

The study was strongly collaborative, benefitting from expertise across the uOttawa Faculty of Medicine’s broad research ecosystem.

The first author is Christopher Bergin, a recent PhD graduate from Dr. Benoit’s lab who methodically tested vanoxerine for its anti-cancer stem cell properties in patient-derived organoids. Dr. Rebecca Auer, scientific director of The Ottawa Hospital’s Cancer Therapeutics Program, provided access to colorectal cancer patients’ tissues. Dr. Mario Tiberi and Dr. Michele Ardolino provided critical insights and expertise.

While working on this study, Dr. Benoit’s lab hosted Dr. Tanguy Fenouil, a gastrointestinal pathologist from France whose collaborative work was key.

Life doesn’t stop at age 65. Get the latest on seniors and healthy aging in the Seniors channel

Original post: Newswise - Substance Abuse Life doesn't stop at age 65. Get the latest on seniors and healthy aging in the Seniors channel

People worldwide are living longer.  According to the World Health Organization, 1 in 6 people in the world will be aged 60 years or over by 2030.  By 2050, the world’s population of people aged 60 years and older will double (2.1 billion). The number of individuals aged 65 years or above across the world will be twice the number of children under age 5 by the year 2050. That makes this population one of the fastest-growing groups in the world.

Below are some of the latest research and features on this growing population of older adults in the Seniors channel on Newswise.

Older adults rely more on trust in decision making. It could open them up to scams.

-University of Florida

Language barriers could contribute to higher aggression in people with dementia

-Edith Cowan University

Sexually transmitted infections among older adults pose a global public health challenge

-University of Oslo

Experts Comment on Aiming for a Romantic Relationship at Any Stage of Life

-University of New Hampshire

Third Major Study Finds Evidence that Daily Multivitamin Supplements Improve Memory and Slow Cognitive Aging in Older Adults

-Brigham and Women’s Hospital

Smartphone app could help prevent falls in older adults

-Binghamton University, State University of New York

Adults With Cognitive Disabilities Are More Likely to Have Worse Experiences With Health Care System

-Institute for Health, Health Care Policy and Aging Research at Rutgers University

Caring for LGBTQ+ nursing home residents in culturally appropriate and inclusive ways

-Regenstrief Institute

Following a Mediterranean diet reduces the risk of cognitive decline in older people

-University of Barcelona

Infection with common cat-borne parasite associated with frailty in older adults

-University of Colorado Boulder