Mixing Large Doses of Both Acetaminophen Painkiller and Caffeine May Increase Risk of Liver Damage

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Consuming large amounts of caffeine while taking acetaminophen, a widely used painkiller, could potentially cause liver damage, according to a preliminary laboratory study. The toxic interaction could occur not only from drinking caffeinated beverages while taking the painkiller but also from using large amounts of medications that intentionally combine caffeine and acetaminophen, the researchers say.