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People who need to drink relatively high amounts of alcohol before feeling its effects, a genetically influenced risk factor for future heavy drinking and alcohol problems, may have differences in brain connectivity that impair their ability to interpret facial expressions and recognize their own intoxication, a new study suggests. The paper, in Alcoholism: Clinical & Experimental Research, is believed to be the first to demonstrate differences in brain connectivity between people with low and high responses to alcohol. Varying levels of responses to alcohol — for example, how many drinks a person consumes before feeling intoxicated — are known to be related to neurobiological processing. Low responders, who drink more alcohol before feeling affected by it, are at greater risk of alcohol use disorder (AUD) than high responders, who feel the effects of fewer drinks. Scientists using functional magnetic resonance imaging (fMRI) are exploring the possibility that low responders are less a